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Catalytic activities of a cocaine hydrolase engineered from human butyrylcholinesterase against (+)- and (−)-cocaine

✍ Scribed by Xue, Liu; Hou, Shurong; Yang, Wenchao; Fang, Lei; Zheng, Fang; Zhan, Chang-Guo


Book ID
121885689
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
480 KB
Volume
203
Category
Article
ISSN
0009-2797

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In humans, the plasma enzyme butyrylcholinesterase, BChE (EC 3.1.1.8), mediates the in vivo plasma hydrolysis of cocaine to the pharmacologically inactive metabolite ecgonine methyl ester, EME. This enzyme has been purified from human plasma to investigate the potential as a treatment for cocaine in