Catalyst-free domino-Knoevenagel-hetero-Diels–Alder reaction of terminal alkynes in water: an efficient one-step synthesis of indole-annulated thiopyranobenzopyran derivatives
✍ Scribed by K.C. Majumdar; Abu Taher; Sudipta Ponra
- Book ID
- 108285745
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- French
- Weight
- 935 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0040-4039
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An efficient synthesis of pentacyclic indole derivatives is achieved via domino Knoevenagel-hetero-Diels-Alder reactions of indolin-2-thiones and O-propargylated salicylaldehyde derivatives in CH 3 CN in the presence of 10 mol % of ZnO as a heterogeneous catalyst. The products are formed in good to
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## Abstract An efficient synthesis of polycyclic indole derivatives is achieved __via__ domino __Knoevenagel__–hetero‐__Diels–Alder__ reaction of __O__‐acrylated salicylaldehyde derivatives with dihydroindole‐2‐thiones in H~2~O as solvent. The products are formed in good‐to‐excellent yields with hi