✦ LIBER ✦
Catalysis of the peptide bond formation by 50 S subunits ofE. Coliribosomes with N-(formyl) methionine ester of adenylic acid as peptide donor
✍ Scribed by V. V. Kotusov; M. K. Kukhanova; A. A. Krayevsky; B. P. Gottikh
- Publisher
- Springer
- Year
- 1976
- Tongue
- English
- Weight
- 275 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0301-4851
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✦ Synopsis
50 S subunits of E. coli ribosomes catalyze the reaction of the 2'(3')-N-(formyl) methionine ester of adenosine 5'-phosphate and Phe-tRNA resulting in peptide bond synthesis. Cytidine 5'-phosphate stimulates this process on 50 S ribosomal subunits as well as on intact ribosomes. The obtained data show that the areas of the peptidyltransferase donor site which binds the 3'-terminal fragment of peptidyl-tRNA possess completely formed structures on 50 S ribosomal subunits.