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Catalysis and Selectivity of Na+ Permeation in Bacterial Sodium Channel NaVAb

✍ Scribed by Ing, Christopher; Chakrabarti, Nilmadhab; Payandeh, Jian; Zheng, Ning; Catterall, William A.; Pomès, Régis

Book ID: 122678220
Publisher: Biophysical Society
Year: 2014
Tongue: English
Weight: 46 KB
Volume: 106
Category: Article
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2013.11.772

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## Structure-function studies have shown that it is possible to convert a sodium channel to a calcium-selective channel by a single amino acid substitution in the selectivity filter locus. Ion permeation through the "model selectivity filter" was modeled with a reduced set of functional groups repr