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Catabolite repression in Escherichia coli mutants lacking cyclic AMP

✍ Scribed by Dessein, Alain ;Schwartz, Maxime ;Ullmann, Agnès

Publisher
Springer
Year
1978
Tongue
English
Weight
388 KB
Volume
162
Category
Article
ISSN
0026-8925

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✦ Synopsis

The regulation of catabolite repression of beta-galactosidase has been studied in Escherichia coli mutants deleted for the adenyl cyclase gene (cya delta), and thus unable to synthesize cyclic AMP. It has been found that, provided a second mutation occurs either in the crp gene coding for the catabolite gene activator protein (CAP) or in the Lactose region, these mutants exhibit catabolite repression. If the catabolite repression seen in the mutant strains corresponds to the mechanism operating in wild-type cells the results would suggest that the intracellular concentration of cyclic AMP cannot be the unique regulator of catabolite repression.

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