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Catabolite repression and nitrogen control of allantoin-degrading enzymes inPseudomonas aeruginosa

✍ Scribed by D. B. Janssen; C. Drift

Publisher: Springer Netherlands
Year: 1983
Tongue: English
Weight: 419 KB
Volume: 49
Category: Article
ISSN: 0003-6072
DOI: 10.1007/bf00399328

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✦ Synopsis

The formation of the allantoin-degrading enzymes allantoinase, allantoicase and ureidoglycolase in Pseudomonas aeruginosa was found to be regulated by induction, catabolite repression and nitrogen control. Induction was observed when urate, allantoin or allantoate were included in the growth medium, but not with ureidoglycolate. Tricarboxylic acid cycle intermediates exerted catabolite repression of the synthesis of the three enzymes, while pyruvate and glucose caused less repression. The operation of a nitrogen control mechanism in the regulation of the allantoin-degrading enzymes could be demonstrated with glutamine synthetase-negative mutants, which showed elevated synthesis and escape from catabolite repression when growth was limited for glutamine.

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Nitrogen control inPseudomonas aeruginosa: A role for glutamine in the regulation of the synthesis of NADP-dependent glutamate dehydrogenase, urease and histidase

✍ Dick B. Janssen; Patricia M. Herst; Han M. L. J. Joosten; Chris Drift 📂 Article 📅 1981 🏛 Springer 🌐 English ⚖ 604 KB

In Pseudomonas aeruginosa the formation of urease, histidase and some other enzymes involved in nitrogen assimilation is repressed by ammonia in the growth medium. The key metabolite in this process appears to be glutamine or a product derived from it, since ammonia and glutamate did not repress ure