Catabolism of aspartate and asparagine byBacteroides intermediusandBacteroides gingivalis
✍ Scribed by Haroun N. Shah; Ralph A. D. Williams
- Publisher
- Springer
- Year
- 1987
- Tongue
- English
- Weight
- 571 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0343-8651
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## Abstract One of the most frequent modifications in proteins and peptides is the deamidation of asparagine, a spontaneous non‐enzymatic reaction leading to a mixture of L,D‐succinimidyl, L,D‐aspartyl, and L,D‐isoaspartyl forms, with L‐isoaspartyl dominating. Spontaneous isomerization of L‐Asp yie
S)-b 2 -Homoamino acids with the side chains of Asp, Glu, Asn, and Gln have been prepared and suitably protected (N-Fmoc, CO 2 t Bu, CONHTrt) for solid-phase peptide syntheses. The key steps of the syntheses are: N-acylation of 5,5-diphenyl-4-isopropyl-1,3-oxazolidin-2-one (DIOZ) with succinic and g