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Castleman's disease with coagulation defect

✍ Scribed by Rizzo, S. C. ;Balduini, C. L. ;Gamba, G. ;Invernizzi, R. ;Grignani, G. ;Mauri, C.

Publisher
Springer-Verlag
Year
1984
Weight
180 KB
Volume
49
Category
Article
ISSN
1432-0584

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✦ Synopsis

The case of a young man with the plasma cell type of Castleman's disease is described. Beyond the well known systemic manifestations the coagulation tests showed a decrease in the activity of factors V, VIII and X due to the presence of lupus-like circulating anticoagulants. After surgical excision of the mediastinal mass both hematochemical pathological data and the coagulation defect disappeared. It is suggested that the lupus-like anticoagulant was secreted by the tumor.

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