## Abstract Glyfoline exhibits cytotoxic activity __in vitro__ and antitumor activity in mice bearing murine or human solid tumors, but the underlying mechanisms are unknown. In our study, we found that glyfoline inhibited cell growth and induced accumulation of mitotic cells in human cancer cell l
โฆ LIBER โฆ
Casticin induces leukemic cell death through apoptosis and mitotic catastrophe
โ Scribed by Jia-Kun Shen; Hua-ping Du; Min Yang; Yun-Gui Wang; Jie Jin
- Book ID
- 105989324
- Publisher
- Springer
- Year
- 2009
- Tongue
- English
- Weight
- 491 KB
- Volume
- 88
- Category
- Article
- ISSN
- 0939-5555
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## Abstract Geldanamycin (GA) binds to heat shock protein 90 (Hsp90) and interferes with its function which is to protect various cellular proteins involved in signaling, growth control, and survival from ubiquitination and subsequent degradation by the proteasome. Recently, we demonstrated that GA