Caspase activation and apoptosis in response to proteasome inhibitors
β Scribed by Henderson, C J; Aleo, E; Fontanini, A; Maestro, R; Paroni, G; Brancolini, C
- Book ID
- 110017033
- Publisher
- Nature Publishing Group
- Year
- 2005
- Tongue
- English
- Weight
- 963 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1350-9047
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The multicatalytic protease complex or proteasome is a fundamental nonlysosomal tool that the cell uses to process or degrade proteins at a fast rate through the ubiquitin and ATP-dependent proteolytic pathway. Examples of these important proteins include the tumor suppressor protein p53, various cy
## Abstract The proteasome is a multiβsubunit protease complex that is involved in intracellular protein degradation in eukaryotes. Previously, we have reported that selective, synthetic chymotryptic proteasome inhibitors inhibit AβNK cellβmediated cytotoxicity by approximately 50%; however, the ex