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Caspase 9 is required for p53-dependent apoptosis and chemosensitivity in a human ovarian cancer cell line

โœ Scribed by Wu, Gen Sheng; Ding, Zhenhua


Book ID
110066247
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
291 KB
Volume
21
Category
Article
ISSN
0950-9232

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The cytotoxicity of Doxorubicin and cis-dichloro-diammineplatinum (DDP) was evaluated in clones, obtained from a human ovarian cancer cell line transfected with a ternperaturesensitive p53 mutant, which express mutant p53 at 37ยฐC and wild-type-like p53 at 32ยฐC. DDP was equally active in cells not ex