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Caspase-9 Activation and Caspase Cleavage of tau in the Alzheimer's Disease Brain

✍ Scribed by Troy T. Rohn; Robert A. Rissman; Michael C. Davis; Young Eun Kim; Carl W. Cotman; Elizabeth Head

Book ID: 115641762
Publisher: Elsevier Science
Year: 2002
Tongue: English
Weight: 390 KB
Volume: 11
Category: Article
ISSN: 0969-9961
DOI: 10.1006/nbdi.2002.0549

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In Alzheimer's disease (AD) synapses degenerate and neurons die in brain regions involved in learning and memory processes. Although the cellular and molecular mechanisms underlying the neurodegenerative process in AD are unclear, increasing evidence suggests roles for amyloid ␤-peptide (A␤) and bio