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Caspase-3-dependent and caspase-3-independent pathways leading to chromatin DNA fragmentation in HL-60 cells

✍ Scribed by X. W. Meng; M. J. Fraser; J. M. Feller; J. B. Ziegler


Book ID
110278774
Publisher
Springer
Year
2000
Tongue
English
Weight
239 KB
Volume
5
Category
Article
ISSN
1360-8185

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## Abstract Exogenous Ξ²~2~‐microglobulin (Ξ²~2~m) induces significant apoptosis in the CCRF‐HSB‐2 human lymphoblastic leukemia cell line as detected by DNA fragmentation, DAPI staining and annexin V binding assay. Ξ²~2~m treatment induced the release of cytochrome c and apoptosis‐inducing factor (AIF