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Caspase-3 Cleavage of GGA3 Stabilizes BACE: Implications for Alzheimer's Disease

✍ Scribed by Robert Vassar


Book ID
116782963
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
194 KB
Volume
54
Category
Article
ISSN
0896-6273

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In Alzheimer's disease (AD) synapses degenerate and neurons die in brain regions involved in learning and memory processes. Although the cellular and molecular mechanisms underlying the neurodegenerative process in AD are unclear, increasing evidence suggests roles for amyloid ␀-peptide (A␀) and bio