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Case report: Cytomegalovirus-induced thrombosis in an immunocompetent patient

✍ Scribed by Michelle L.M. Poon; Julian W. Tang; Dr. Yen Lin Chee

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
107 KB
Volume
84
Category
Article
ISSN
0146-6615

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✦ Synopsis

Abstract

Thrombotic manifestations of cytomegalovirus infection in immunocompetent individuals are rare. However, it has been postulated that cytomegalovirus infection can be both directly cytopathic and capable of inducing antiphospholipid antibodies due to shared β€œmolecular mimicry” between cytomegalovirus virus antigens and antiphospholipid antibodies. The case of a previously well 30‐year‐old woman with primary cytomegalovirus infection complicated by splenic infarction and massive pulmonary embolus is described. The patient is unusual given the development of thromboses affecting both the arterial and venous circulation, associated with both transient anticardiolipin antibodies and persistently positive anti‐β~2~glycoprotein I antibodies. The temporal relationship between the primary infection and thrombosis was suggestive of a pathogenic role for cytomegalovirus. J. Med. Virol. 84:116–118, 2011. Β© 2011 Wiley Periodicals, Inc.

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