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Case-control study of familial lung cancer risks in UK women

✍ Scribed by Athena Matakidou; Tim Eisen; Helen Bridle; Mary O'Brien; Rosalind Mutch; Richard S. Houlston; Members of the GELCAPS Consortium

Publisher
John Wiley and Sons
Year
2005
Tongue
French
Weight
86 KB
Volume
116
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Family history data from a case‐control study of lung cancer conducted in the United Kingdom between 1999 and 2004 were analysed to estimate familial risks of the disease. Comparison of lung cancer prevalence in first‐degree relatives of 1,482 female lung cancer cases and 1,079 female controls was undertaken using logistic regression adjusting for age and tobacco exposure. Overall, lung cancer in a first‐degree relative was associated with a significant increase in the risk of lung cancer [odds ratio (OR) 1.49; 95% confidence interval (CI), 1.13–1.96]. For cases with early onset of the disease (< 60 years), the OR of lung cancer was 2.02 (95% CI, 1.22–3.34). Having 2 or more affected relatives was associated with an OR of 2.68 (95% CI, 1.29–5.55), with a significant trend in risk according to the number of relatives affected (p = 0.001). An increased risk of lung cancer associated with family history of the disease was observed when analysis was restricted to lifetime nonsmokers, although this did not reach significance (OR 1.23; 95% CI, 0.65–2.31). Results confirm previous findings and support the role of a familial predisposition to lung cancer. © 2005 Wiley‐Liss, Inc.

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