Case-Control Association Testing with Related Individuals: A More Powerful Quasi-Likelihood Score Test
β Scribed by Timothy Thornton; Mary Sara McPeek
- Book ID
- 117855229
- Publisher
- American Society of Human Genetics
- Year
- 2007
- Tongue
- English
- Weight
- 310 KB
- Volume
- 81
- Category
- Article
- ISSN
- 0002-9297
- DOI
- 10.1086/519497
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π SIMILAR VOLUMES
Genome-wide association studies typically test large numbers of genetic variants in association with trait values. It is well known that linkage disequilibrium (LD) between nearby markers tends to introduce correlation among association tests. Failure to properly adjust for multiple comparisons can
## Abstract In caseβcontrol single nucleotide polymorphism (SNP) data, the allele frequency, Hardy Weinberg Disequilibrium, and linkage disequilibrium (LD) contrast tests are three distinct sources of information about genetic association. While all three tests are typically developed in a retrospe