Cascade filtration with reverse rinse of the secondary filter

✍ Scribed by Professor Mauro Valbonesi; Giuseppe Lercari; Gerardo Angelini; Libera Malfanti; Mauro Ferrari; Emanuele Russo; Sandro Nati

• Publisher: John Wiley and Sons
• Year: 1987
• Tongue: English
• Weight: 367 KB
• Volume: 3
• Category: Article
• ISSN: 0733-2459
• DOI: 10.1002/jca.2920030410

✦ Synopsis

With cascade filtration (CF) secondary filter plugging may render some procedures difficult, particularly with cryoglobulinemia or macroglobulinemia patients, when filters are subjected to the most consistent burden. To prcvenl plugging. in the initial management of seven patients with cryoglobulinemia or macroglobulinemia we cmployed polyniethylmethacrlate sccondary filters produced by Toray Industries Inc., Tokyo. with pores calculated at 0.1 p m (QS-12-70). In the subsequent sessions, when circulating macroproteins were reduced to more acceptable levels, sccondary filters with pores of 0.06 Km were used (QS-12-50). The filtration efficiency of both filtcrs was maintained throughout the procedures with reverse rinses carried out when the transmembrane pressure from the values of 80-130 nim Hg reached the values of 250 mm Hg. With this improved technique, 2.6-3.31 liccrs of plasma could be treated, producing adequate clinical benefits. From a laboratory point of view, the differential-sieving for albumin and macroglobulins was 61 % for the QS-12-50 filters and 56% for the QS-12-70 models.