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CAS, the Human Homologue of the Yeast Chromosome-Segregation Gene CSE1, in Proliferation, Apoptosis, and Cancer

โœ Scribed by Ulrich Brinkmann


Book ID
117852337
Publisher
American Society of Human Genetics
Year
1998
Tongue
English
Weight
284 KB
Volume
62
Category
Article
ISSN
0002-9297

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MSH6 has been implicated in repair of single base mispairs and single-base deletion/insertion mutations. Established MSH6-null mice present a frequent occurrence of gastrointestinal tumors without microsatellite instability (MI), suggesting the possibility of the APC gene being a mutational target.