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Carvedilol-liposome interaction: evidence for strong association with the hydrophobic region of the lipid bilayers

✍ Scribed by Hung-Yuan Cheng; Cynthia S. Randall; Walter W. Holl; Panayiotis P. Constantinides; Tian-Li Yue; Giora Z. Feuerstein


Book ID
115731305
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
768 KB
Volume
1284
Category
Article
ISSN
0005-2736

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Liposomes consisting of egg yolk phosphatidylcholine and hydrophobic peptides Nps-and C1--+H,-(Met-Met-Leu),-OEt ( n = 6-10) with various polypeptide chain lengths were prepared by the sonication method. The conformation of the peptides incorporated into the liposomes was examined by CD spectroscopy