Cartilage proteoglycans in synovial fluid and serum in patients with inflammatory joint disease. relation to systemic treatment

✍ Scribed by Tore Saxne; Dick Heineg ård; Frank A. Wollheim

• Publisher: John Wiley and Sons
• Year: 1987
• Tongue: English
• Weight: 700 KB
• Volume: 30
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/art.1780300903

✦ Synopsis

Relation to Systemic Treatment TORE SAXNE, DlCK HEINEGARD. and FRANK A. WOLLHEIM Proteoglycan concentrations in knee joint synovial fluid and in serum from patients with various inflammatory arthritides were studied using an enzymelinked immunosorbent assay. Patients with reactive arthritis, calcium pyrophosphate arthropathy, and juvenile rheumatoid arthritis (age 5 2 0 years) had the highest synovial fluid concentrations. These values differed significantly (P < 0.001) from those in patients with rheumatoid arthritis, psoriatic arthropathy, and chronic HLA-B27-associated arthropathy . Rheumatoid arthritis patients receiving low-dose prednisolone treatment had higher synovial fluid (P = 0.006) and serum (P <: 0.001) proteoglycan concentrations than did those taking nonsteroidal antiinflammatory drugs or slowacting antirheumatic drugs. Serum proteoglycan concentrations were near the detection limits, and did not correlate with levels found in paired samples of knee joint synovial fluid. Patients with calcium pyrophosphate arthropathy had the highest mean serum level of proteoglycan. This assay of proteoglycan antigens is a From the