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Cartilage oligomeric matrix protein in serum and synovial fluid of rheumatoid arthritis: potential use as a marker for joint cartilage damage

✍ Scribed by Shigeki Momohara; Hisashi Yamanaka; Masumi Maruo Holledge; Tamao Mizumura; Katsunori Ikari; Naoyuki Okada; Naoyuki Kamatani; Taisuke Tomatsu


Publisher
Springer
Year
2004
Tongue
English
Weight
264 KB
Volume
14
Category
Article
ISSN
1439-7595

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Objective. To determine whether matrix metalloproteinases (MMPs) degrade cartilage oligomeric matrix protein (COMP) to produce fragments similar to those found in synovial fluid (SF) from patients with arthritis. Methods. COMP fragments were generated in vitro by treating (a) bovine articular carti