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Carrier detection of duchenne/becker muscular dystrophy: Computer-assisted direct quantitation of gene amplification products

✍ Scribed by Ishii, Keiko; Sakuraba, Hitoshi; Minamikawa-Tachino, Reiko; Shimmoto, Michie; Suzuki, Yoshiyuki


Book ID
123304119
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
578 KB
Volume
14
Category
Article
ISSN
0387-7604

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Carrier status determination for Duchenne and Becker muscular dystrophies (D/BMD), disorders caused by mutations in the dystrophin gene at Xp21, is complicated by a number of factors. These include a high mutation rate and a 5-10% recombination frequency across the dystrophin gene. For these reasons