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Carrier detection and feasibility of prenatal diagnosis of hemophilia B by multiplex polymerase chain reaction

✍ Scribed by Luigina Tagliavacca; Elisabetta Sacchi; Pier Mannuccio Mannucci

Book ID
110573256
Publisher
Springer
Year
1993
Tongue
English
Weight
335 KB
Volume
23
Category
Article
ISSN
0940-5437

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Carrier detection and prenatal diagnosis
Carrier detection and prenatal diagnosis of alpha-thalassemia of Southeast Asian deletion by polymerase chain reaction
✍ Tsang-Ming Ko; Li-Hui Tseng; Fon-Jon Hsieh; Pi-Mei Hsu; Tzu-Yao Lee πŸ“‚ Article πŸ“… 1992 πŸ› Springer 🌐 English βš– 523 KB

Alpha-thalassemia of Southeast Asian deletion (--SEA/) is very common in Southeast Asia. Homozygosity of this genotype is the major cause of Hb Bart's hydrops fetalis in Taiwan. With polymerase chain reaction using three oligonucleotide primers bridging the common deletion breakpoint, a DNA fragment