Carrier-bound methotrexate. II. Water-soluble polyaspartamide methotrexate conjugates with amide links in polymer–drug spacer

Carrier-bound methotrexate. I. Water-sol

Carrier-bound methotrexate. I. Water-soluble polyaspartamide–methotrexate conjugates with ester links in the polymer–drug spacer

✍ M. G. Meirim; E. W. Neuse; D. D. N'Da 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 122 KB 👁 1 views

## Abstract The antifolate‐type anticancer drug methotrexate (MTX) has for many years, in numerous laboratories, been a “workhorse” drug for conjugation with natural and synthetic macromolecular carriers for the purpose of enhancing bioavailability and lowering toxic side effects. In the project he