Carotenoids, vitamin A and risk of adenomatous polyp recurrence in the polyp prevention trial

✍ Scribed by Susan Steck-Scott; Michele R. Forman; Anne Sowell; Craig B. Borkowf; Paul S. Albert; Martha Slattery; Brenda Brewer; Bette Caan; Electra Paskett; Frank Iber; Walt Kikendall; James Marshall; Moshe Shike; Joel Weissfeld; Kirk Snyder; Arthur Schatzkin; Elaine Lanza; The Polyp Prevention Trial Study Group

• Publisher: John Wiley and Sons
• Year: 2004
• Tongue: French
• Weight: 114 KB
• Volume: 112
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.20364

✦ Synopsis

Abstract

One trial reported beta‐carotene supplementation was protective of adenomatous polyp recurrence in nonsmokers. We now examine the relation of serum and dietary carotenoids and vitamin A to adenomatous polyp recurrence in a subcohort of 834 participants in a low fat, high fiber, high fruit and vegetable dietary intervention, the Polyp Prevention Trial. Multivariate odds ratio (OR) and 95% confidence intervals (CI) of polyp recurrence were obtained using baseline or the average (first 3 years of the trial) carotenoid and vitamin A values after adjustment for covariates. Compared to the lowest quartile of baseline alpha‐carotene concentrations, the OR of multiple polyp recurrence for the highest quartile was 0.55 (95% CI = 0.30–0.99) and the OR of right‐sided recurrence was 0.60 (95% CI = 0.37–0.95). Baseline dietary intakes of alpha‐carotene and vitamin A from food with/without supplements were inversely associated with any recurrence (p~for linear trend~ = 0.03‐ alpha‐carotene; p = 0.004 and p = 0.007 ‐intakes of vitamin A). Compared to the lowest quartile of averaged beta‐carotene concentrations, the OR of multiple adenomas for the highest quartile was 0.40 (95% CI = 0.22–0.75) with an inverse trend (p = 0.02). The risk was inversely related to averaged: alpha‐carotene concentrations and right‐sided polyps; alpha‐carotene intake and recurrence of any, multiple and right‐sided polyps; beta‐carotene intake and multiple adenoma recurrence; vitamin A from food (with supplements) and each adverse endpoint. Thus, alpha‐carotene and vitamin A may protect against recurrence in nonsmokers and nondrinkers or be indicative of compliance or another healthy lifestyle factor that reduces risk. © 2004 Wiley‐Liss, Inc.