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Cardiovascular responses to noradrenaline microinjection in the ventrolateral periaqueductal gray of unanesthetized rats

✍ Scribed by Gislaine Garcia Pelosi; Rodrigo Fiacadori Tavares; José Antunes-Rodrigues; Fernando Morgan Aguiar Corrêa

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
274 KB
Volume
86
Category
Article
ISSN
0360-4012

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✦ Synopsis

Abstract

The periaqueductal gray area (PAG) is a mesencephalic area involved in cardiovascular modulation. Noradrenaline (NA), a neurotransmitter involved in central blood pressure control, is present in the rat PAG. We report here on the cardiovascular effects caused by NA microinjection into the ventrolateral PAG (vlPAG) of unanesthetized rats and the peripheral mechanism involved in their mediation. NA microinjection in the vlPAG of unanesthetized rats evoked dose‐related pressor and bradycardiac responses. No significant cardiovascular responses were observed in urethane‐anesthetized rats. The pressor response was potentiated by pretreatment with the ganglion blocker pentolinium (5 or 10 mg/kg, intravenously). Pretreatment with the vasopressin antagonist dTyr(CH~2~)~5~ (Me)AVP (50 μg/kg, intravenously) blocked the pressor response evoked by the NA microinjection into the vlPAG. Additionally, circulating vasopressin content was found to be significantly increased after NA microinjection in the vlPAG. The results suggest that activation of noradrenergic synapses within the vlPAG modulates vasopressin release in unanesthetized rats. © 2007 Wiley‐Liss, Inc.

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