Cardiovascular response to dopamine in hypotensive preterm neonates with severe hyaline membrane disease
✍ Scribed by I. Seri; T. Tulassay; J. Kiszel; T. Machay; S. Csömör
- Publisher
- Springer
- Year
- 1984
- Tongue
- English
- Weight
- 636 KB
- Volume
- 142
- Category
- Article
- ISSN
- 0340-6997
No coin nor oath required. For personal study only.
✦ Synopsis
The effect of low dose (2, 4, and 8 lag/kg per rain) dopamine infusion on blood pressure, heart rate and renal function was studied in 18 hypotensive, preterm infants with severe hyaline membrane disease (HMD). Significant dose-. related effects found during dopamine infusion were systolic and diastolic blood pressure elevation and diuretic effect, while heart rate increase occurred only with 8 gg/kg per rain of the drug. This indicates, that in the preterm neonate, dopamine at low doses has a pronounced effect on the alphaand dopamine-receptors, while its beta-receptor stimulating activity is minimal. We demonstrated a significantly decreased metabolic clearance rate of dopamine in preterm infants. Thus, beside the differences in the vascular receptors' maturation, the decreased metabolic clearance rate should also be taken into account when explaining the cardiovascular and renal effects of low dose dopamine infusion in these babies. Dopamine was found to be useful in normalizing low arterial blood pressure, in improving impaired peripheral circulation, and in producing a marked diuresis in hypotensive preterm neonates with severe hyaline membrane disease.