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Cardiovascular response, feeding behavior and locomotor activity in mice lacking the NPY Y1 receptor

✍ Scribed by Pedrazzini, Thierry; Seydoux, Josiane; Künstner, Pierre; Aubert, Jean-François; Grouzmann, Eric; Beermann, Friedrich; Brunner, Hans R.

Book ID: 109929074
Publisher: Nature Publishing Group
Year: 1998
Tongue: English
Weight: 581 KB
Volume: 4
Category: Article
ISSN: 1078-8956
DOI: 10.1038/nm0698-722

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Neuropeptide Y (NPY) is primarily synthesised and released by neurones, it is co-localised with noradrenaline and is involved in the regulation of cardiovascular function. In a mouse model lacking NPY Y1 receptor (KO), the ability of NPY to potentiate noradrenaline-induced vasoconstriction is abolis