Cardiovascular Magnetic Resonance Spectroscopy

✍ Scribed by Gregory G. Schwartz, Michael W. Weiner (auth.), Saul Schaefer M.D., Robert S. Balaban Ph.D. (eds.)

• Publisher: Springer US
• Year: 1993
• Tongue: English
• Leaves: 231
• Edition: 1
• Category: Library

✦ Synopsis

The application of magnetic resonance spectroscopy (MRS) to the cardiovascular system is a relatively new phenomenon. Its ability to noninvasively examine myocardial metabolism has led to its use to answer basic questions in animal models of normal and diseased myocardium. Extension of these investigations into the realm of human myocardial metabolism has been made possible by the advent of relatively high-field magnets with spectroscopy capabilities and sufficient bore dimensions to allow human studies. While ongoing and future studies promise to enhance our understanding of myocardial metabolism, their success will, in part, depend on a thorough understanding of the technical and biologic aspects of cardiovascular MRS, as well as the current state of research in the many areas encompassed by this discipline.
It is with concept that the present monograph has been written. The organization and content should lend this book to both the beginning reader who is interested but not conversant in cardiovascular MRS, as well as to the active investigator who wishes to refer to a volume that deals with the many issues of this field in a concise but complete manner. The monograph is structured with a general overview of the field, followed by a section addressing the technical issues of cardiovascular MRS. The next section is devoted to biologic issues of both normal and abnormal myocardial metabolism, primarily devoted to investigations employing phosphorus-31. This is followed by a section dealing with more specialized issues, generally involving other nuclei such as protons, carbon, and sodium. Finally, the clinical applications of cardiovascular MRS are addressed.

✦ Table of Contents

Front Matter....Pages i-ix
Magnetic Resonance Spectroscopy: Basic Principles and Potential Applications in the Study of the Cardiovascular System....Pages 1-10
Experimental Models in Cardiac Magnetic Resonance Spectroscopy....Pages 11-23
Instrumentation and Strategies for in Vivo Human Cardiac Phosphorus NMR Spectroscopy....Pages 25-43
Localization Methods for Cardiovascular Magnetic Resonance Spectroscopy....Pages 45-62
Nuclear Magnetic Resonance Studies of Kinetics and Regulation of Oxidative ATP Synthesis in the Myocardium....Pages 63-92
Nuclear Magnetic Resonance Studies of Myocardial Metabolic Responses to Alterations in Workload....Pages 93-110
Magnetic Resonance Spectroscopy of Myocardial Ischemia....Pages 111-125
Metabolic Effects of Chemotherapy on the Heart....Pages 127-142
31 P Magnetic Resonance Spectroscopy Studies of Skeletal Muscle: New Insights into the Pathophysiology of Congestive Heart Failure....Pages 143-152
Substrate Metabolism in the Citric Acid Cycle of the Heart by 13 C NMR....Pages 153-168
NMR Studies of Glycogen Metabolism in the Heart....Pages 169-183
1 H NMR Studies of the Cardiovascular System....Pages 185-193
Measuring Sodium Movements Across the Myocardial Cell Wall Using 23 N A NMR Spectroscopy and Shift Reagents....Pages 195-213
Clinical Applications of Cardiac Spectroscopy....Pages 215-224
Back Matter....Pages 225-230

✦ Subjects

Spectroscopy/Spectrometry; Spectroscopy and Microscopy; Nuclear Medicine; Cardiology; Internal Medicine