Cardiovascular effects of bulbocapnine

✍ Scribed by T. Fakouhi; T. D. Darby; R. S. McCutcheon

• Publisher: John Wiley and Sons
• Year: 1971
• Tongue: English
• Weight: 389 KB
• Volume: 60
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600600709

✦ Synopsis

concluded from the values of KAB and percent biophasic availability listed in Tables I1 andI11 that it is opposite to that expected on the basis of this consideration alone. The increased percent biophasic availability observed at pH 5.0 as equal to 73.8 %, relative to 43.3 at pH 7.4, may be speculatively attributed to the interaction of tropicamide cations with anionic binding sites affixed to the colloids composing the corneal tissue; the tissue binding of the drug may function to retard peripheral drug loss relative to transcorneal absorption and provide a reservoir for the drug from which it may be subsequently more efficiently biophasically available. A similar mechanism was found responsible for the pH-enhanced effectiveness of procaine as a corneal anesthetic (1). The small magnitude of the effect of administering the drug at 5.0 relative to 7.4 may be a consequence of the dilution of the unbuffered pH 5.0 vehicle with lacrimal fluid, causing its rapid buffering to a physiological pH of 7.4.