Cardiovascular effects of amitriptyline, mianserin and zimelidine in depressed patients
β Scribed by Burgess, Carl D.; Montgomery, Stuart A.; Montgomery, Deider B.; Wadsworth, Jane
- Book ID
- 122340781
- Publisher
- Elsevier Science
- Year
- 1980
- Weight
- 258 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0364-7722
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Thirteen elderly depressed patients (age 60-82 years) were treated for 5 weeks with a fixed dose of amitriptyline 100 mg (sustained release preparation). In all patients the sum of concentrations of amitriptyline and nortriptyline exceeded 130 gg/1, which is the recommended plasma level. Cardiovascu
Six healthy male volunteers took part in this three-period crossover study. In each session, a dose of trial drug -- either placebo, zimelidine 200 mg, or amitriptyline 75 mg -- was given at 09.00 h. Ethanol (50 g) was taken orally at 1200 h. Blood samples were taken for measurement of drug and etha