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Cardiorespiratory and Neuromuscular Effects of O-Ethyl S-[2- (Diisopropylamino) Ethyl] Methylphosphonothioate (VX) in Rats

✍ Scribed by S. N. Dube; P. K. Mazumder; D. Kumar; Purnanand

Book ID
105828435
Publisher
Springer
Year
1997
Tongue
English
Weight
118 KB
Volume
59
Category
Article
ISSN
0007-4861

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## O-Isobutyl S-[2-(diethylamino)ethyl]methylphosphonothioate (VR) is a structural isomer of a more well-known chemical warefare agent, O-ethyl S-[2(diisopropylamino)ethyl]methylphosphonothioate (code designation VX ). In this study, cardiorespiratory and central nervous system (CNS) effects of VR

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Herein a molecular mechanic study of the interaction of a lethal chemical warfare agent, O-ethyl S-[2-(diisopropylamino)ethyl] methylphosphonothioate (also called VX), with Torpedo californica acetylcholinesterase (TcAChE) is discussed. This compound inhibits the enzyme by phosphonylating the active