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Cardioinhibitory peptides fromLimulus polyphemus: modulation of the neurogenic heart

✍ Scribed by G. Gaus; M. Casaretto; H. Stieve

Publisher: Springer-Verlag
Year: 1994
Tongue: English
Weight: 437 KB
Volume: 164
Category: Article
ISSN: 0174-1578
DOI: 10.1007/bf00354079

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✦ Synopsis

Four neuropeptides have been isolated and sequenced from acetone extracts of brains of the horseshoe crab Limulus polyphemus. They belong to a newly discovered peptide family in invertebrates. A possible role of the four peptides from Limulus as cardioregulatory neurotransmitters has been tested on the isolated Limulus heart. Three of the peptides (DEGHKMLYFamide, GH-SLLHFamide, and PDHHMMYFamide) produce dosedependent decreases in both amplitude and rate of the heart contractions, whereas DHGNMLYFamide reduces only the amplitude of the heartbeat. All four peptides differ in threshold, potency and duration of their effects.

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