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Cardiac sympathetic innervation and blood flow regulation of the diabetic heart

✍ Scribed by Oliver Schnell

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
39 KB
Volume
17
Category
Article
ISSN
1520-7552

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✦ Synopsis

Abstract

A key problem in ischemia‐induced impairment of the vascular performance of the diabetic heart is the often‐unrecognized cardiac sympathetic dysfunction. Advanced single‐photon emission computed tomography (SPECT) and positron emission tomography (PET) using the radiopharmaceuticals, ^123^I‐metaiodobenzylguanidine (^123^I‐MIBG) and ^11^C‐hydroxyephedrine (^11^C‐HED), have shown that dysfunction of cardiac sympathetic nerves is present to a large extent in both type 1 and type 2 diabetes. The pattern of sympathetic disturbances is heterogeneous with a predominant effect in the posterior myocardial region. Furthermore, myocardial blood flow assessment with PET has shown that endothelial‐dependent vasodilatation is reduced in proportion to the magnitude of cardiac sympathetic dysfunction. These mechanisms are currently proposed to lead from early changes to advanced impairment of cardiac function in diabetes. Copyright © 2001 John Wiley & Sons, Ltd.

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