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Cardiac specification of embryonic stem cells

✍ Scribed by Claudine Ménard; Corinne Grey; Annabelle Méry; Dana Zeineddine; Franck Aimond; Michel Pucéat

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
211 KB
Volume
93
Category
Article
ISSN
0730-2312

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✦ Synopsis

Abstract

Over the past decade, cell transplantation has been recognized as a mean of repairing infarcted myocardium. Both adult stem cells and differentiated cells have yielded encouraging results with regard to engraftment into postinfarction scars. However, these cells now feature serious restrictions. As an alternative, embryonic stem (ES) cells are particularly attractive, because of their plasticity and the subsequent possibility to drive them towards a cardiomyogenic phenotype after exposure to appropriate growth factors. An additional theoretical advantage of ES cells is their expected immune privilege. In this article, we summarize the findings obtained in cell therapy using ES cells and discuss the molecular mechanisms of cardiac specification of the cells. © 2004 Wiley‐Liss, Inc.

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