Cardiac sensitization induced by phenobarbitone and prolonged by CS2

✍ Scribed by Ian Eastwood; Philip J. Forshaw; Jeyarajah Jeyeratnam; Laszlo Magos

• Book ID: 104737523
• Publisher: Springer-Verlag
• Year: 1977
• Tongue: English
• Weight: 193 KB
• Volume: 37
• Category: Article
• ISSN: 0340-5761
• DOI: 10.1007/bf00355493

✦ Synopsis

The arrhythmogenic effect of 8 ~xg/kg noradrenaline given i.v. was increased in male rats pretreated 1-2 days earlier with phenobarbitone and starved from the time of the first phenobarbitone injection (80 mg/kg followed by 50 mg/kg 6 h later). Daily exposure to 4.0 mg/l CS2 (first exposure 24 h after the first phenobarbitone injection) for 4 h prevented the decline in susceptibility on the 3rd and 4th days after phenobarbitone, when the reaction of unexposed rats to noradrenaline returned to normal.