𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Cardiac potential of stem cells from whole human umbilical cord tissue

✍ Scribed by Kai Hong Wu; Xu Ming Mo; Bin Zhou; Shi Hong Lu; Shao Guang Yang; Ying Long Liu; Zhong Chao Han

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
306 KB
Volume
107
Category
Article
ISSN
0730-2312

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

We investigated the role of stem cells from human umbilical cord tissue in cardiomyocyte regeneration. The umbilical cord stem cells were initially characterized and differentiated in a myocardial differentiation medium containing 5‐azacytidine for 24 h. Differentiation into cardiomyocytes was determined by expression of cardiac specific markers, like cardiac α‐actin, connexin43, myosin, Troponin T, and ultrastructural analysis. In vivo, the transplanted umbilical cord stem cells were sprouting from local injection and differentiated into cardiomyocyte‐like cells in a rat myocardial infarction model. Echocardiography revealed increasing left ventricular function after umbilical cord stem cell transplantation. These results demonstrate that umbilical cord stem cells can differentiate into cardiomyocyte‐like cells both in vitro and in vivo. Therefore, human umbilical cord might represent a source of stem cells useful for cellular therapy and myocardial tissue engineering. Future studies are required to determine the molecular signaling mechanisms responsible for this phenomenon. J. Cell. Biochem. 107: 926–932, 2009. © 2009 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Human umbilical cord mesenchymal stem ce
Human umbilical cord mesenchymal stem cells: Osteogenesis in vivo as seed cells for bone tissue engineering
✍ Yinze Diao; Qingjun Ma; Fuzhai Cui; Yanfeng Zhong 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 965 KB

## Abstract Mesenchymal stem cells (MSCs) are ideal seed cells for bone tissue engineering. However, intrinsic deficiencies exist for the autologous transplantation strategy of constructing artificial bone with MSCs derived from bone marrow of patients. In this study, MSCs‐like cells were isolated

Neural differentiation and potential use
Neural differentiation and potential use of stem cells from the human umbilical cord for central nervous system transplantation therapy
✍ Choon Bing Low; Yih-Cherng Liou; Bor Luen Tang 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 102 KB 👁 1 views

## Abstract The human umbilical cord is a rich source of autologous stem and progenitor cells. Interestingly, subpopulations of these, particularly mesenchymal‐like cells from both cord blood and the cord stroma, exhibited a potential to be differentiated into neuron‐like cells in culture. Umbilica

Retinoic acid-mediated induction of neur
Retinoic acid-mediated induction of neurons and glial cells from human umbilical cord-derived hematopoietic stem cells
✍ Y.K. Jang; J.J. Park; M.C. Lee; B.H. Yoon; Y.S. Yang; S.E. Yang; S.U. Kim 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 539 KB

## Abstract Recent studies reporting trans‐differentiation of mononucleated cells derived from human umbilical cord blood into neuronal cells aroused interest among investigators for their clinical implication and significance in regenerative medicine. In the present study, purified populations of

Neurogenic potential of human umbilical
Neurogenic potential of human umbilical cord blood: Neural-like stem cells depend on previous long-term culture conditions
✍ M. Jurga; I. Markiewicz; A. Sarnowska; A. Habich; H. Kozlowska; B. Lukomska; L. 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 480 KB

In vitro studies conducted by our research group documented that neural progenitor cells can be selected from human umbilical cord blood (HUCB-NPs). Due to further expansion of these cells we have established the first human umbilical cord blood-derived neural-like stem cell line (HUCB-NSC) growing