✦ LIBER ✦

Cardiac pathology in chronic myopathy, with particular reference to dystrophia myotonica

✍ Scribed by A. J. Franks

Publisher: John Wiley and Sons
Year: 1978
Tongue: English
Weight: 810 KB
Volume: 125
Category: Article
ISSN: 0022-3417
DOI: 10.1002/path.1711250407

No coin nor oath required. For personal study only.

✦ Synopsis

Histological changes in the hearts of two patients with dystrophia myotonica and one patient with a familial scapulo-peroneal myopathy are described. The myocardium showed fibre hypertrophy, interstitial fibrosis, vacuolar degeneration of myocardial cells and focal groups of aberrantly orientated myofibres. The AV node in the case of scapulo-peroneal myopathy showed vacuolar fibre degeneration and fatty infiltration. The aberrantly orientated myofibres have not previously been described in this context, and their relationship to similar aberrant fibres in hypertrophic obstructive cardio-myopathy and the electrophysiological and clinical manifestations of cardiac involvement in myotonic dystrophy are discussed.

📜 SIMILAR VOLUMES

Experience with the use of adriamycin in

Experience with the use of adriamycin in combination with other anticancer agents using a weekly schedule, with particular reference to lack of cardiac toxicity

✍ Arthur J. Weiss; Roland W. Manthel 📂 Article 📅 1977 🏛 John Wiley and Sons 🌐 English ⚖ 477 KB 👁 1 views

Two hundred and seven patients have been treated using a weekly regimen of Adriamycin i n combination with various other anticancer agents. Thirty-six of these patients have received between 600 and 1000 mg/m2 of Adriamycin and 27 have received more than 1000 mg/m2 of the agent. While electrocardiog

Pathology of chronic hepatitis b virus i

Pathology of chronic hepatitis b virus infection in children: With special reference to the intrahepatic expression of hepatitis B virus antigens

✍ Dr. Hey-Chi Hsu; Yon-Ho Lin; Mei-Hwei Chang; Ih-Jen Su; Ding-Shinn Chen 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 English ⚖ 698 KB

The clinical, virologic and pathologic features of chronic hepatitis B virus infection were studied in 66 children, of whom 29 were symptomatic and 37 asymptomatic. The majority (79%) of symptomatic children had histologically aggressive diseases: 11 had chronic active hepatitis and 10 had cirrhosis

Acute and Chronic Toxicity of Veratrum V

Acute and Chronic Toxicity of Veratrum Viride††The Veratrum viride studied was the whole-powdered drug marketed by Irwin, Neisler & Co. under the name, Vertavis. The work reported herein was supported by a grant from this firm. The batch of powder used in these experiments was stated by the manufacturer to have been assayed biologically by the Craw method on Daphnia magna. One Craw unit of the material studied was stated to be 15.6mg. With regard to this assay, Mr. R. O. Craw has been so kind as to allow us to publish a brief explanation: A reference lot of Yerolrum oirid; powder was set-aside as a standard and a 10% w/v aqueous extract was made of this powder. The average median length of life in 50 assays of 1000 daphnia on immersion in the solution was determined to be 2.22 hours. The daphnia were considered dead when the heart was found to be in systolic standstill on microscopic examination. Succeeding lots of powder were assayed and their potency determined by relating the median length of life of daphnia to 2.22 hours, which is one unit. Twenty assays of 10 animals each were used on each lot of powder.‡‡The authors wish to thank Dr. J. F. A.,McManus of the Department of Pathology for a pathologic report on the tissues, and Mr. James Thomas and Mrs. Bobby E. Teague for technical assistance.

✍ Perdue, Adoline S. ;Bell, Frances ;Starnes, W.R. ;Hitchcock, Philip ;Teague, R.S 📂 Article 📅 1950 🏛 Elsevier ⚖ 346 KB 👁 1 views