## Abstract We have reโexamined some of the factors affecting the induction of heartโforming mesodern in the axolotl. The formation of functional, rhythmically contracting myocardial tissue was used as an assay. We have found that heartโforming mesoderm is fully induced and capable of completing it
Cardiac mutant salamanders: Evidence for heart induction
โ Scribed by Kulikowski, Robert R. ;Manasek, Francis J.
- Publisher
- John Wiley and Sons
- Year
- 1977
- Tongue
- English
- Weight
- 322 KB
- Volume
- 201
- Category
- Article
- ISSN
- 0022-104X
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โฆ Synopsis
Abstract
Homozygosity for gene c in Ambystoma mexicanum results in no detectable heartbeat in situ. Alteration of the cardiac environment through organ culture results in rapid initiation of spontaneous heartbeat, indicating that absence of cardiac function in situ is not the result of failure of embryonic induction.
๐ SIMILAR VOLUMES
Recessive mutant gene c for "cardiac nonfunction" in axolotls results in an absence of normal heart contractions in affected embryos due to a failure of myofibril formation. In the present study, the intermediate filament protein, desmin, is compared in developing normal and mutant hearts by means o
We isolated a neonatal skeletal myosin heavy chain (MHC) cDNA clone, CV11E1, from a cDNA library of embryonic chick ventricle. At early cardiogenesis, diffuse expression of neonatal skeletal MHC mRNA was first detected in the heart tube at stage 10. During subsequent embryonic stages, the expression