Cardiac gap junctions: three distinct single channel conductances and their modulation by phosphorylating treatments

Regulation of cardiac gap junction chann

Regulation of cardiac gap junction channel permeability and conductance by several phosphorylating conditions

✍ Brenda R. Kwak; Habo J. Jongsma 📂 Article 📅 1996 🏛 Springer 🌐 English ⚖ 677 KB

Short term (15 min) effects of activators of protein kinase A (PKA), PKC and PKG on cardiac macroscopic (g(j)) and single channel (gamma j) gap junctional conductances were studied in pairs of neonatal rat cardiomyocytes. Under dual whole-cell voltage-clamp, PKC activation by 100 nM TPA increased g(