Cardiac 17O MRI: Toward direct quantification of myocardial oxygen consumption
✍ Scribed by Kyle S. McCommis; Xiang He; Dana R. Abendschein; Pradeep M. Gupte; Robert J. Gropler; Jie Zheng
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 447 KB
- Volume
- 63
- Category
- Article
- ISSN
- 0740-3194
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✦ Synopsis
Abstract
A new ^17^O‐labeled blood contrast agent was injected intravenously in control dogs. Electrocardiogram (ECG)‐triggered myocardial T~1~ρ imaging was performed to obtain spin‐locking T~1~ρ‐weighted myocardial signals for the detection of resultant metabolite H~2~^17^O water in the heart. Bolus and slow injection methods of various doses of the ^17^O‐labeled and ^16^O‐labeled agents were carried out in order to evaluate the sensitivity of this method and determine the optimal injection method. Bolus injection provided approximately 1% signal reduction, whereas slow injection with larger amount of agent yielded 11.9 ± 0.6% signal reduction. Myocardial oxygen consumption rate was determined by a technique to quantify cerebral oxygenation consumption rate previously developed in ^17^O brain studies. With either injection method, myocardial oxygen consumption rate at rest was 5.0 – 5.6 μmol/g/min. Therefore, it appears feasible to detect metabolically generated HO water in vivo in the heart, using the ^17^O‐labeled blood tracer. Myocardial oxygen consumption rate can then be quantified in vivo, which may open new doors for the assessment of myocardial metabolism. Magn Reson Med 63:1442–1447, 2010. © 2010 Wiley‐Liss, Inc.