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CARD15gene and the classification of Crohn's disease

✍ Scribed by Laura Murillo, Bart J. Crusius, Ad A. van Bodegraven, Behrooz Z. Alizadeh, Salvador A. Peña

Publisher
Springer-Verlag
Year
2002
Tongue
English
Weight
22 KB
Volume
54
Category
Article
ISSN
0093-7711

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Three common mutations in the CARD15 (NOD2) gene are known to be associated with susceptibility to Crohn disease (CD), and genetic data suggest a gene dosage model with an increased risk of 2-4-fold in heterozygotes and 20-40-fold in homozygotes. However, the discovery of numerous rare variants of C