## Abstract The epidermal growth factor receptor (EGFR) tyrosineโkinase inhibitor gefitinib (Iressaยฎ, ZD1839) has shown promising activity preclinically and clinically. Because comparative investigations of drugโresistant sublines with their parental cells are useful approaches to identifying the m
โฆ LIBER โฆ
Carcinomatous meningitis from non-small-cell lung cancer responding to gefitinib
โ Scribed by Mitsuaki Sakai; Shigemi Ishikawa; Hiromichi Ito; Yuichiro Ozawa; Tatsuo Yamamoto; Masataka Onizuka; Yuzuru Sakakibara
- Publisher
- Springer
- Year
- 2006
- Tongue
- English
- Weight
- 301 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1341-9625
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## Abstract The epidermal growth factor receptor (EGFR) signaling pathway is often activated in NSCLC, and thus represents a promising therapeutic target. We studied the antitumor activity of gefitinib (Iressaโข), an orally active EGFRโtyrosine kinase inhibitor, alone and in combination with standar