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Carcinoma of unknown primary in the head and neck: Comparison between positron emission tomography (PET) and PET/CT

✍ Scribed by Florian Keller; Georgios Psychogios; Rainer Linke; Michael Lell; Torsten Kuwert; Heinrich Iro; Johannes Zenk

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
209 KB
Volume
33
Category
Article
ISSN
1043-3074

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✦ Synopsis

Background. Comparison of the diagnostic validity of positron emission tomography (PET) alone with integrated PET and CT (PET/CT) in the search for occult primary tumors in patients with cancer of unknown primary (CUP) site in the head and neck.

Methods. Thirty-nine consecutive patients with clinical CUP were investigated with PET and 38 patients with PET/CT. After initial diagnostic panendoscopy and histological confirmation of the cervical lymph node metastasis, either PET or PET/CT scanning was performed.

Results. Integrated PET/CT had a significantly higher overall detection rate than dedicated PET alone (55.2% vs 30.8%; p ¼ .039) and positive prediction rate (93.3% vs 46.1%; p ¼ .01).

Conclusion. Integrated PET/CT showed to be superior to PET in the detection of the primary site of clinically occult tumors in CUP syndrome. However, a negative result should still be investigated further by means of panendoscopy with tonsillectomy and blind biopsies. V

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