Carcinoma of the prostate: Prognostic evaluation of certain pathologic features in 208 radical prostatectomies

✍ Scribed by David P. Byar; F. K. Mostofi; The Veterans Administration Cooperative Urological Research Group

• Publisher: John Wiley and Sons
• Year: 1972
• Tongue: English
• Weight: 709 KB
• Volume: 30
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/1097-0142(197207)30:1<5::aid-cncr2820300103>3.0.co;2-s

✦ Synopsis

In a study of 208 total prostates removed surgically for early carcinoma of the prostate and studied by the step-section technique, we found that 97% were located either peripherally or both peripherally and centrally; 80% were bilateral, and 85% were multifocal. In most of the cases, the tumor was actually more extensive than detected by rectal examination, but there was reasonable agreement (74.5%) between the urologist and pathologist in assessing the presence of local extension of carcinoma. Evaluation of various factors affecting survival and mortality disclosed that an extension of the tumor to seminal vesicles or invasion of the capsule, whether detected clinically or pathologically, had an unfavorable prognosis while the side involved, the location of the tumor, and perineural invasion had no significant effect on the prognosis.

NUMBER OF PREVIOUS PATHOLOGIC STUDIES

evaluate the findings in relation to survival. A A of carcinoma of the prostate based on number of total prostatectomy specimens obthe technique of step-sections are avail-tained through the VA Cooperative Urological able,6s9J2 but these have been retrospective Research Group afforded us an unusual o p studies confined to the prostate gland removed portunity to evaluate certain pathologic findat autopsy rather than surgical total prosta-ings in relation to survival and mortality. It tectomy specimens and, in none of these is our purpose here to report these findings. studies, has there been the opportunity to

MATERIALS