Carcinoma of the male breast: A review of adjuvant therapy
โ Scribed by Vinod, Shalini K ;Pendlebury, Susan C
- Book ID
- 104470074
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 41 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0004-8461
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โฆ Synopsis
The purpose of the present paper was to evaluate the characteristics and outcomes of male breast cancer patients seen for adjuvant therapy at a single institution. A retrospective review of computerized records in the Departments of Medical and Radiation Oncology at the Royal Prince Alfred Hospital (RPAH) was undertaken. Between 1983 and 1996, 24 men were referred for treatment of breast cancer. Of these, 19 had localized breast cancer, four had metastatic disease and one had ductal carcinoma in situ (DCIS). The median age was 57.5 years (range: 26โ78) and median followโ up was 6.2 years (range: 0.6โ36). Pathological staging was performed. Survival was assessed using actuarial life table analysis. Of the 19 patients who presented with localized disease, there were 12 T~1~ , five T~2~ and two T~4~ cancers. Eleven patients had axillary lymph node involvement. Ten patients were oestrogen receptor (ER) positive, two patients were ER negative and seven patients had unknown receptor status. All patients underwent surgery. Eleven patients received radiotherapy. The median dose and dose per fraction were 50 Gy and 2 Gy, respectively. Adjuvant systemic therapy was delivered to 10 patients, of whom nine were nodeโpositive. Four patients received chemotherapy alone, three patients received chemotherapy and tamoxifen, and three patients received tamoxifen only. Seven patients relapsed (one local, five distant, one both). Of the two patients with local relapses, one had received radiotherapy. Of the distant failures, four of six patients had no systemic therapy. There were only two nodeโpositive patients who were not given systemic treatment and both relapsed. Median survival in all patients with invasive cancer was 7.5 years, and in those with localized disease it was 7.6 years. The median survival of nodeโpositive patients was 3.8 years. In nodeโnegative patients the median survival had not been reached at a median followโup of 6.2 years. The majority of patients (12/14) with known receptor status were ER+, a finding that parallels those of other studies. Local control rates were 88% (7/8) in patients who had mastectomy alone and 91% (10/11) in those patients receiving adjuvant radiotherapy. Systemic therapy was found to be beneficial in patients with nodeโpositive disease. Chemotherapy was administered more frequently than hormonal therapy. The median survivals were consistent with those reported in other series.
๐ SIMILAR VOLUMES
## Abstract ## BACKGROUND Traditional nonparametric statistical methods do not provide a quantitative measure of the lifetime benefit from adjuvant therapy. This deficiency makes it difficult to determine the longโterm difference in impact between the two treatment arms of a clinical trial. ## ME
## Background: Tamoxifen therapy for patients with breast carcinoma is perceived as an independent risk factor for venous thromboembolic events (vte), but the risk associated with other adjuvant therapies is less well recognized. ## Methods: The authors conducted a computerized pubmed literature
## Abstract Sixteen new patients with carcinoma of the male breast presented to St Bartholomew's Hospital in the 20-year period from 1952 to 1971. Twelve (75 per cent) had Stage III or Stage IV disease. Seven of those in Stage III were thus classified by reason of the advanced (T3) local lesions an