Carcinoid tumors of the lung: Immuno- and ligandohistochemistry, analysis of integrated optical density, syntactic structure analysis, clinical data, and prognosis of patients treated surgically
✍ Scribed by Kayser, Klaus; Kayser, Corinna; Rahn, Wolfgang; Bovin, Nicolai V.; Gabius, Hans-Joachim
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 688 KB
- Volume
- 63
- Category
- Article
- ISSN
- 0022-4790
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✦ Synopsis
Background: Analysis of potentially prognostic relevant factors of carcinoid tumors of the lung.
Methods: Clinical features, tumor size, and features derived from immuno-and ligandohistochemistry, cytometry and histometry, and survival have been analyzed in 82 potentially curatively resected carcinoid tumors of the lung.
Results: Patients with typical carcinoid tumors had a longer history of symptoms (1 3 vs. 8 months), fewer smoked (30% vs. 80%), and developed less frequently lymph node metastases (20% vs. 65%) compared to patients with atypical carcinoids. Statistically significant differences between both cell types have been observed in cytometric and histometric features, and binding of Lewis A trisaccharide (Lea). Prognosis is associated with the cell type, presence of lymph node metastases and heparin-binding lectin (HBL), certain cytometric and structural features, and binding of macrophage migration inhibitory factor (MIF) and P-N-acetyl-D-galactosamine (P-GalNAc).
Conclusions: Complete lymph node dissection is necessary, data of cytometry, histometry, and ligandohistochemistry might eventually predict the course of the disease.