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Carcinogenicity of catechol estrogens in Syrian hamsters

✍ Scribed by Joachim G. Liehr; Fang Wan-Fen; David A. Sirbasku; Aysegul Ari-Ulubelen

Book ID
116005447
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
467 KB
Volume
24
Category
Article
ISSN
0022-4731

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## Abstract To examine a possible mechanism of endogenous estrogen‐induced carcinogenesis, we studied the effect of the catechol‐__O__‐methyltransferase (COMT) inhibitor Ro 41‐0960 on cell transforming and clastogenic activities of 2 catechol estrogens 2‐ and 4‐hydroxyestrone (2‐ or 4‐OHE~1~) using