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Carcinogenic potential of some pesticides in a medium-term multi-organ bioassay in rats

✍ Scribed by Ricardo Cabral; Ryohci Hasegawa; Toru Hoshiya; Kazuo Hakoi; Tadashi Ogiso; Plcumjit Boonyaphiphat; Tomoyuki Shirai; Nobuyuki Ito


Publisher
John Wiley and Sons
Year
1993
Tongue
French
Weight
466 KB
Volume
54
Category
Article
ISSN
0020-7136

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✦ Synopsis


The carcinogenic potential of 5 pesticides was analyzed using a medium-term multi-organ bioassay for carcinogenicity. Male F344 rats were initially treated with 3 known carcinogens (diethylnitrosamine, N-methyl-N-nitrosourea and N-bis(2-hydroxypropy1)nitrosamine) during a period of 4 weeks to induce neoplastic changes in a variety of organs, and then given one of 5 pesticides in the diet for a further 16 weeks. Neoplastic